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KMID : 1035620160040030174
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Allergy Asthma & Respiratory Disease
2016 Volume.4 No. 3 p.174 ~ p.180
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Clinical characteristics of interferon-gamma-inducible protein of 10 kDa in children with wheezing
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Kim Beom-Joon
Bae Kil-Seong
Kim Hwan-Su
Chun Yoon-Hong
Yoon Jong-Seo
Kim Hyun-Hee
Kim Jin-Tack
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Abstract
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Purpose: Recent studies have shown that interferon-gamma-inducible protein of 10 kDa (IP-10/CXCL10) levels is increased in acute bronchiolitis and asthma. The aim of this study was to examine the levels of IP-10 in children with wheezing and whether it correlates with other clinical variables.
Methods: A total of 62 subjects children were hospitalized for lower respiratory tract infection with wheezing and visited the Emergency Department due to an acute exacerbation of asthma. IP-10 levels were measured using enzyme-linked immunosorbent assay in the serum collected at admission. Serum IP-10 levels were evaluated for the relationships with age, sex, blood eosinophils counts, acute phase reactant, allergic sensitization, history of wheezing, and chest X-ray findings.
Results: Age showed a significant negative correlation with serum IP-10 levels (P=0.002). The serum levels of IP-10 were also significantly increased in patients with pneumonic infiltration on X-rays compared to those with normal or hyperinflation (P<0.009). There was no significant difference in the serum IP-10 level according to the other factors, including allergic sensitization.
Conclusion: Serum IP-10 is significantly associated with inflammation of the lung and age, but not with allergic inflammation.
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KEYWORD
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Interferon-gamma-inducible protein of 10 kDa, Wheezing, Child
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